But research suggests the accumulation causes inflammation that damages the myelin sheath. Scientists aren’t exactly sure how the VLCFA buildup affects the body. ![]() As a result, VLCFAs build up in the brain, nervous system and adrenal cortex, the largest part of the adrenal gland. ![]() People with ALD can’t break down high levels of fat molecules - specifically very-long-chain fatty acids (VLCFAs). DNA contains genetic building blocks - the instructions for how your body works. What is a genetic disorder?Ī genetic disorder results from a mutation (change) in part of your DNA. Treatments aim to slow the progression and improve people’s quality of life. ALD affects the nervous system and the adrenal glands.ĪLD is a progressive disease. ![]() Adrenoleukodystrophy (ALD) is one of a group of genetic disorders called leukodystrophies.
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